M5LQW

Prompt

1.14.16.2

Oxidoreductases. Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporated need not be derived from O2. With reduced pteridine as one donor, and incorporation of one atom of oxygen. tyrosine 3-monooxygenase.

AI Generated Sequence

295 AAs

MDKEKPVFTEPDNERGAVNIFLSLKNEVGSLVKALKVFQETKVNLVHIESRKSRRLNSEFEYFVDCESHRQLDAIIGQLKSAHNILSVNTPPEHFNDDKKDEDKVPWFPRKISELDKCAHQILKYGSDLDADHPGFSDVYRQKRRKYFADIAFNYKHGDPIPRVEYTAEEIKTWKTVYKTLKSLYPTHACHEYLHAFSLLEKYCGYREDNIPQLEDVSRFLKSTTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASDPMHSPEPDVCHELLGHVPMLADPTFAQFSQEIGL

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT	83.6
NLMSIM	90.0
AACOMP	92.6
Seqdif (SeqID)	27.5 (NXM05102.1)
Structdif (F-Target)	36.1 (7zih A)

ProtNLM

Name	Score
1.14.16.2	0.288
Tyrosine 3-monooxygenase	0.194
TY3H monooxygenase	0.077
Tyrosine 3-monooxygenase-like	0.051
Tryptophan 5-monooxygenase	0.048
Tyrosine 3-hydroxylase	0.048