M5IYN

Prompt

1.13.11.34

Oxidoreductases. Acting on single donors with incorporation of molecular oxygen (oxygenases). The oxygen incorporated need not be derived from O2. With incorporation of two atoms of oxygen. arachidonate 5-lipoxygenase.

AI Generated Sequence

228 AAs
MPSYKVTVATGDYLFAGTDNYLYLSLVGTEGCESKQLLDKPLFNDFERGAVESYDVQCDEDLGPLQLVKIEKKHYWLPDDWYCKCITVTSPTGDAVEFPCYRWITGEEGVTLRDGTAKIPRDDMLQILKQHRRKELEERQKNYRWKEWIPGFPMNIDATDIHDLPRDIQFDSEKGIDFILNYSKAIENLFIRFMHMFQSWSDFDAFEKIFIQINTSISEYVMQHWQED

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT79.6
NLMSIM90.0
AACOMP90.5
Seqdif (SeqID)28.3 (XP_044617581.1)
Structdif (F-Target)20.9 (4nre A)

ProtNLM

NameScore
Arachidonate 5-lipoxygenase0.261
Arachidonate 5-lipoxygenase-like0.123
Hydroperoxide isomerase ALOXE3-like0.109
Hydroperoxide isomerase ALOXE30.074
Arachidonate 5-lipoxygenase a0.057
Arachidonate 5-lipoxygenase b, tandem duplicate 20.038
Designed by MP, using an AMD MI250 GPU