M5GGM

Prompt

1.1.1.20

Oxidoreductases. Acting on the CH-OH group of donors. With NAD(+) or NADP(+) as acceptor. glucuronolactone reductase.

AI Generated Sequence

820 AAs

MASFVVLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAVYGNEAEIGEALREEVGPGKAIPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFPRPADGTMRYDITHYKETWKAMEKLVDKGLVKAIGLSNFNSRQIDDVLSVASVKPAVLQVECHPYVAQNELIAHCQKRGLVVTAYSPLGSPDRAWKHPDEPVLLEEPGVLKIAEKYGKSPAQIILRWQVQRKVVCIPKSVTPARILQNIQVFDFSLTPEEMEQIGALNKGNWRYIVPMITVNGKSVPRDATHPLYPFNDPYSPGQSSFIDHYETRLILLSMEPEAKKQGKSISIIDYPKDADALVDLVKKLTDLQLDYLDLYLMHWPYAFERGDNLVTPNQYRDVTKWMEELVADKGLVKAIGLSNFNSRQIDDVLSVASVRPAVLQVECHPYLAQNELIAHCQSRGLEVTAYSPLGSPDRAWKPDPDEPVLLEEPSVLKIAEKYGKSPAQIILRWQVQRRKVCIPKSVTPEARIQELNQVFDSFTLSPEEMEHIGALNKGNWRYIVPMITVDGKKVPRDATHPLLPFNDPYSPSQEKFIRYHETRILPLLLGLPPKEAEKLWDDVKNTSWKTIMEAVDKGLVKAIGLSNFNPRQIDDVLSVASVKPAVLQVECHPYLAQNELIAHCQSRGLEVTAYSPLGSPDRAWKPDPEEPVLLEEPSVLKIAEKYGKSPAQIILRWHVQRKVVCIPKSVTPERIQELNQVFDFTSLSPEEMEQIGALNKGNWRYIVPMITVDGKRVPRDAGHELLPFNDPYS

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT	74.8
NLMSIM	60.0
AACOMP	93.7
Seqdif (SeqID)	12.9 (XP_051044518.1)
Structdif (F-Target)	2.9 (3h4g A)

ProtNLM

Name	Score
Aldehyde reductase	0.152
Alcohol dehydrogenase [NADP(+)]	0.128
1.1.1.54	0.124
1.1.1.372	0.100
Glucuronolactone reductase	0.079
1.1.1.2	0.078