M5ANV

Prompt

1.13.11.34

Oxidoreductases. Acting on single donors with incorporation of molecular oxygen (oxygenases). The oxygen incorporated need not be derived from O2. With incorporation of two atoms of oxygen. arachidonate 5-lipoxygenase.

AI Generated Sequence

665 AAs
MPNYKVTVATGSQLFAGTDNYLYLSLVGERGCSEKQLLDKPFYRNFERGAVEDYQVTVDEELGDILLVKLEKRKWFRDDSWYCKYITVKTPTGDYVEFPCYRWITGDREVELREGRARTPSDDTIQILKQHRRQELETQRQFYRWESWIPGFPLSIDASCHLDDLPRDDQFDENKGIDFTLNAALEAMYNRFMQLMQSSWSDFDDFKRIFGVKSNTLSEYVMHHWQEDEMFGYQFLNGCNPMLIRRCSELPEKLPVTPDMVESFLESRNTLEQELENGNIFIADFELLDGIPANTIDCTQQYLAAPLCLLLKYNANGKLMPIAIQLNQPPGPENPPIFLPSDSAWDWLLAKIWVRSSDFHVHQISTHLLRTHLVAEVFSVATMRQLPALHPVFKLLVPHFHYTMSINTIARGELICEGGLFDKVNSTGGGHVQLVKRALDTLTYSSLCFPEEIGRDIPSFYYARDGLRVWDAIKSFVSEVIHVYYKSDEVVQRDPELQSWCQDIFVEGFMRGRDSGFPKELQSRQELCEFVTMVIFTCTAQHAAINFGQLDWYSWIPNPPCTMRPPPPTTKGTVTIEEMITTLPDNGRACHMLGVVWLLSRFQDRPLVLGMYQEQHFLEKPVKEAMARFRQDLAAISDMINERNSKMKLPYEYLSPKRIENSVAI

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT87.3
NLMSIM90.0
AACOMP94.1
Seqdif (SeqID)34.1 (NWU54364.1)
Structdif (F-Target)2.7 (4nre A)

ProtNLM

NameScore
Arachidonate 5-lipoxygenase0.285
LOX5 lipoxygenase0.205
Arachidonate 5-lipoxygenase-like0.067
ALOX50.055
LOX12 lipoxygenase0.030
Arachidonate 12-lipoxygenase, 12R-type0.024
Designed by MP, using an AMD MI250 GPU