M59G2

Prompt

1.1.1.239

Oxidoreductases. Acting on the CH-OH group of donors. With NAD(+) or NADP(+) as acceptor. 3alpha-(17beta)-hydroxysteroid dehydrogenase (NAD(+)).

AI Generated Sequence

500 AAs
MDLLQEKFFLGLLGVLCVVCLKKVFLCFCKKLCWLYYLVPKTFFRSMGQWAVVTGAGDGIGKAYAFELARQGLNVVLISRTLEKLQAIAAEIESTTGRSVKIIQADFTKDDIYDFIYEKLKGLDIGILVNNVGMLPNLLPSHFLNTPENIQSIIHCNITSVVKMTQLILKHMESRRKGLILNISSGVALFPWPLYSMYSASKAFVCTFSKGLQAEYKAKGIIIQTLAPYGVSTPMTKYLKTNLITKTADEFVKESLNYVTIGDETCGSLAHEILGAFLNLIPRCIYENSASLQAVLYWLMRLKYLKRHRVLAWRKRLYGWAVVTGASDGIGKAYSFELARQGLNVVLISRTLEKLQAIAAEIEVTTGRSVKIIQADFTKDDIYDFIEKKLKGLDIGILVNNCGMLPNLLPSHFLNTPDIEQLIHCNITSVVKMTQLILKHMEDRRKGLILNISSGVALFPWPLYSMYSASKAFVCTFSKGLQAEYKAKGIIIQTLAPFGV

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT90.9
NLMSIM90.0
AACOMP92.6
Seqdif (SeqID)23.6 (XP_060465852.1)
Structdif (F-Target)25.7 (8aew B)

ProtNLM

NameScore
Hydroxysteroid 17-beta dehydrogenase 30.782
Estradiol 17-beta-dehydrogenase 30.033
Hydroxysteroid (17-beta) dehydrogenase 30.024
Testosterone 17-beta-dehydrogenase 30.020
DHB3 dehydrogenase0.020
HSD17B30.010
Designed by MP, using an AMD MI250 GPU