M4K7T

Prompt

1.1.1.127

Oxidoreductases. Acting on the CH-OH group of donors. With NAD(+) or NADP(+) as acceptor. 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase.

AI Generated Sequence

500 AAs

MSDLSFSLEGKRALVTGANTGLGQGMALGLARAGADIVVANIEVPEETAERVRALGRRFLSLTGGDLRSVDGGELIDRAVAEFGRLDILVNNAGLIRREDALDFSEDDWDDVMNVNLKSVFLMSQAVGRHFIAQGNGKIINIASMLSFQGGIRVPSYTASKSGVAGVTRLLANEWAKHGINVNAIAPGYMATNNTAQLRADEQRSNEILDRIPAGEWGRPEDLAGTAVFLASPASDYVNGYILPVDGGWLARGDAVIRMDGREYTPEAIAAAEAVGGRIAIVSADLSFQGGIRVPSYTASKSGVAGITRLLANEWAGHGINVNAIAPGYMATNNTQALRADEQRSKNILDRIPAGEWGRPEDLAGTVVFLASPASDYVNGVILPVDGGWLARGDAVTVAELAKRLGRPVTIVNIASMLSFQGGIRVPSYTASKSGVAGLTRMLANEWAGHGINVNAIAPGYMATNNTQALRADERSNAEILARIPAGEWGRPEDLGGVVV

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT	82.3
NLMSIM	70.0
AACOMP	91.6
Seqdif (SeqID)	19.6 (WP_185670018.1)
Structdif (F-Target)	2.8 (4z9y B)

ProtNLM

Name	Score
2-deoxy-D-gluconate 3-dehydrogenase	0.367
2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase KduD	0.157
1.1.1.127	0.102
SDR family oxidoreductase	0.062
3-ketoacyl-ACP reductase	0.061
2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase	0.056