M4D2U

Prompt

1.8.1.16

Oxidoreductases. Acting on a sulfur group of donors. With NAD(+) or NADP(+) as acceptor. glutathione amide reductase.

AI Generated Sequence

464 AAs

MADFDVDLFVIGAGSGGVRAARVAAGLGARVAIAEEYRVGGTCVIRGCVPKKLFVYASHFPEEFEDAAGFGWTVGEARFDWPTLIANKDREIARLNGLYRKNLEKNGVEIFESRARLVDPHTVRLVGDGREVTAEHILIATGGRPNHPPDIPGHELCISSNEAFHLPELPKRILIAGGGYIAVEFANIFHGLGSETTLIYRGEEILSRFDEDLRRGLHEAMEKKGIRILCHDIVQRIEKTEDGSLRATLRNGELVEVDQVMLAIGRIPNTEGLGLEAVGVELDKRGAILVDEYSRTNVPNIYAVGDVTDRVQLTPVAIHEAMCFIETVFKNNPTRPDHELIPTAVFTQPEIGTVGLSEEEAREKYGELEIYRTSFRPMKATLSGRDERTLMKLVVCAETDKVLGVHILGPDAGEMAQLLGIAVKAGATKADFDRTMAVHPTAAEELVTMYTPSYRIYKNGRVDF

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT	90.8
NLMSIM	75.0
AACOMP	92.9
Seqdif (SeqID)	25.1 (WP_075850701.1)
Structdif (F-Target)	3.5 (4dna B)

ProtNLM

Name	Score
1.8.1.7	0.486
GRase	0.255
Glutathione reductase	0.248
Dihydrolipoyl dehydrogenase	0.002
Thioredoxin reductase	0.001
NADPH-glutathione reductase	0.001