M47OG

Prompt

1.1.98.5

Oxidoreductases. Acting on the CH-OH group of donors. With other, known, acceptors. secondary-alcohol dehydrogenase (coenzyme-F420).

AI Generated Sequence

214 AAs
MTIGILGGTGDAGRGLALRWARAGHEVILGSRDPARAEAAVAALAPAVAGADNAAAAAAADVVVLAVPWEGHAATLAALAPDLAGKLVVDCVPNLGFDKAGAYALPPAEGSAAAQLAALLPGSRVVAAFHNLSAAVLADVAPDLDCDLLVVGDDAAARDTVAELAARIPGMRGVYAGRLANAAQVEALTANLISVNRRYKAHAGLRITGVPADL

Ligand/Cofactor

coenzyme F425

CC(C(=O)NC(CCC(=O)NC(CCC(=O)O)C(=O)O)C(=O)O)OP(=O)(O)OCC(C(C(CN1C2=CC(=O)C=CC2=CC3=C1NC(=O)NC3=O)O)O)O

Validation Metrics

PLDDT90.7
NLMSIM85.0
AACOMP80.2
Seqdif (SeqID)30.8 (WP_189918431.1)
Structdif (F-Target)4.0 (5n2i D)

ProtNLM

NameScore
NADPH-dependent F420 reductase0.598
Reduced coenzyme F420:NADP oxidoreductase0.261
F420_oxidored domain-containing protein0.041
F420-dependent NADP reductase0.035
Oxidoreductase0.023
NADP oxidoreductase coenzyme F420-dependent0.005
Designed by MP, using an AMD MI250 GPU