M3YQU

Prompt

1.14.13.127

Oxidoreductases. Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporated need not be derived from O2. With NADH or NADPH as one donor, and incorporation of one atom of oxygen. 3-(3-hydroxy-phenyl)propanoic acid hydroxylase.

AI Generated Sequence

556 AAs
MKTILTQFSAGGLVIVAGGAGGIELATQLGKKLGRKGAIDIVLVSDRSHFQWKPLLHEVAVGTLDSRAIALPYSRHARQHHFQFLLGSVVDIDREAKTITLAEVLDEHGVERRLAYDTLVMALGSVTNDFNTPGVKENCIFLDNPHQAQRFHQEMLNLFLKYSAGVTAERINVAIVGGGATGVELSAELHAFVKQLVDYGYRGVSNELRITLVEAGERILPALPERISAAAEHELQRLGVEVLTNTMVKSADENGLHTKDGEKIPADLMVWSAGIKAPTFLKDFGELQTNRIRTLLVADTLQTTGDDNVYAMGDCASAAREGFSFFPPRAQAAQQAGTMAANNILRMLENKALKPFTYKDHGSLVNLSNYSTVGSLLGMNLAGSMMVEGRAARVYMKSLYMRHQLTVLYGFTKTLLLFGDAMFNIRRPNKAKLHLNGGTWEEIKAVIDRYGNAPGGYQDDDAIQKKWGALDRWAHSFTVREAQQMKQNGIVQRLGIVDLQLKGRYMHPVAAVIADGTRPQRYATALDAQFGAAVQALAGGVAVARCPHDAVYAQKV

Ligand/Cofactor

NADH

C1C=CN(C=C1C(=O)N)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O

Validation Metrics

PLDDT74.0
NLMSIM60.0
AACOMP94.9
Seqdif (SeqID)33.0 (WP_167575976.1)
Structdif (F-Target)7.3 (5na4 A)

ProtNLM

NameScore
FAD-dependent oxidoreductase0.290
NADH dehydrogenase0.265
NAD(P)/FAD-dependent oxidoreductase0.180
1.6.99.30.106
NADH dehydrogenase FAD-containing subunit0.031
Pyridine nucleotide-disulfide oxidoreductase0.020
Designed by MP, using an AMD MI250 GPU