M3WGE

Prompt

6.3.2.37

Ligases. Forming carbon-nitrogen bonds. Acid--amino-acid ligases.(peptide synthases). UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--D-lysine ligase.

AI Generated Sequence

500 AAs
MKILELLKENPEIEISGITTDSREVKPGDTFFALKGAKFDGHKYIQEAIENGAVTIVAEKPLEIPVDVPAIVVPDPRKAMGYLAAAFYGHPSKDLIVIGVTGTNGKTTTAYMIEAILEAAGYKTGLLSTIGYKIGDEIIESGLTTPDPIELQRMLREMVENGCTHAVMEASSHALAQHRVHGCDFDVAVFTNLTQDHLDYHGTMEDYFAAKARLFQTLKPSKAVINLDDPYGELVKEATPEIEVITYGLDKDADVRAENIEMTPEGTSFKLHGPFGETEVESKLIGRFNVYNALAAIAVGLAAGIDLEKIAEGLEHITGVPGRMERVTAGQPFTVIVDYAHTPDALENVLTAAREITPGRIICVFGCGGDRDRTKRPQMGEIAAELADVVILTSDNPRTEDPEAILADIEAGIERAENVYEIIPDRKEAIRRAIEMAEPGDIVLIAGKGHETYQIIGEGKEYPFDDREVAREALERIGHEYEEEEEEEEEEEEEEEEEEE

Ligand/Cofactor

ATP

C1=NC(=C2C(=N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)N

Validation Metrics

PLDDT95.2
NLMSIM85.0
AACOMP89.3
Seqdif (SeqID)43.6 (WP_307402774.1)
Structdif (F-Target)8.7 (4c12 A)

ProtNLM

NameScore
UDP-MurNAc-tripeptide synthetase0.203
Meso-diaminopimelate-adding enzyme0.195
6.3.2.130.167
UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase0.139
UDP-N-acetylmuramyl-tripeptide synthetase0.103
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase0.095
Designed by MP, using an AMD MI250 GPU