M3MO5

Prompt

1.1.1.23

Oxidoreductases. Acting on the CH-OH group of donors. With NAD(+) or NADP(+) as acceptor. histidinol dehydrogenase.

AI Generated Sequence

491 AAs

MSLLDLLRGDGLSEAELRKLLTRREVDEADVIDTVRAIVDDVRHRGDVAVIDYTRRFDRLLTPESLRVPAAEIERALDAVDPALREALELAAERIRVFHERQRLEDHDYTDELGVLTGQKWTPVERAGLYVPGGLAAYPSSVLMNAVPAQVAGVERIVMVVPTPDGGRLNPLILAACRLAGVTEVYRVGGAQAVAALAYGTETICPVDKITGPGNAYVAAAKRLVFGKVGIDSIAGPSEILIVADKTANPVHVAADLLSQAEHDEAAQSILITDSAEFARAVEAAVERQLATLERAEIARASLDGQGAIVLVRDLDEAIRLVNRYAPEHLEIQVADPEALAPRIRNAGAIFVGRWTPESIGDYVAGSNHVLPTGRSARFSSGLSVDSFLKRTSLLKCTEQGLRKLGPAAVALAEAESLPGHARSIALRLEKLDEEGLPLPDGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT	89.2
NLMSIM	90.0
AACOMP	88.2
Seqdif (SeqID)	33.0 (HLO78399.1)
Structdif (F-Target)	3.8 (4g09 2)

ProtNLM

Name	Score
HDH	0.383
Histidinol dehydrogenase	0.320
1.1.1.23	0.185
Histidinol-phosphate aminotransferase	0.064
Histidinol-phosphate transaminase	0.008
Imidazole acetol-phosphate transaminase	0.007