M3MK1

Prompt

1.1.1.85

Oxidoreductases. Acting on the CH-OH group of donors. With NAD(+) or NADP(+) as acceptor. 3-isopropylmalate dehydrogenase.

AI Generated Sequence

414 AAs

MTKKYKIAVLPGDGIGPEVMAEALKVLDAVAKKYGFDFEYTEYDVGGAAIDAHGKPLPDATLKACEASDAILFGAVGGPKWDHVPYDVKPRAGLLLPLRKEFGLFANLRPCKLYPGLKDASSLKAEIIDGLDIVIVRETTGDIYFGEQPKGRETPAGMERAIDTEVYHRFEIRRIARVAFELARKRNNKLTCVDKANVLRSGVLWREIVTEIAKKYPDVQLSHMYIDNATMQLVKDPWQFDVILCSNLFGDILSDLCAMITGSMGMLPSANLNATGFGLFEPSGGSAPDIAGKGKANPIAQILSAAMMLDYSLGLGGAADKIEAAIAAVLADGYRTGDLAPGGLATTSVGDMIGAAIAAALKGKAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT	90.3
NLMSIM	95.0
AACOMP	84.6
Seqdif (SeqID)	30.9 (WP_056235964.1)
Structdif (F-Target)	2.8 (6xxy B)

ProtNLM

Name	Score
3-isopropylmalate dehydrogenase	0.252
3-IPM-DH	0.199
IMDH	0.193
1.1.1.85	0.181
Beta-IPM dehydrogenase	0.169
4.2.1.85	0.000