M3DY7

Prompt

1.14.19.17

Oxidoreductases. Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporated need not be derived from O2. With oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water. sphingolipid 4-desaturase.

AI Generated Sequence

296 AAs
MAAAHPEIKTLMGPDPHLKWVVSGLVFLQLLTCYLVRDASWWKIFFWAYAFGGCINHSLTLAIHEISHNLAFGNKPLYNRWFAIFANLPIGVPYSISFKKYHIEHHRFLGVDHLDVDIPTDFEGWFFCTPLRKFFWVFLQPFFYALRPLMVYPKPITRLEILNALVQLSFDYAIYYFWGLKPLVYLIASTFLGCGLHPIAGHFIAEHYMFLKGQETYSYYGPLNLLTFNVGYHNEHHDFPSIPGCRLPMVKKIAPEFYDNLPHHKSWIKVLWDFVFDTKPPRYRLARKAAKAKLES

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT90.6
NLMSIM70.0
AACOMP89.7
Seqdif (SeqID)22.7 (KFZ51522.1)
Structdif (F-Target)26.6 (8f6t A)

ProtNLM

NameScore
1.14.19.170.442
Degenerative spermatocyte homolog 10.264
Sphingolipid delta(4)-desaturase DES10.152
Dihydroceramide desaturase-10.034
DEGS1 desaturase0.028
Sphingolipid 4-desaturase0.021
Designed by MP, using an AMD MI250 GPU