M2QTW

Prompt

1.14.13.8

Oxidoreductases. Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporated need not be derived from O2. With NADH or NADPH as one donor, and incorporation of one atom of oxygen. flavin-containing monooxygenase.

AI Generated Sequence

530 AAs
MKHVVIIGAGASGLSAAIKCLEEGLEPVTFEQSVDNIGGWHFMTPLPEGVASSVYESTTISLPERMTCFSDFPFPDRPNYMEHPKVLEYIKLYAEKFDLEPDYLFVTGSVKVSRHFGDPGTEWKVDVTESENGQQNIRADFVMACTGHSTPHLPLEEALPGFTIFGGQHHSVEFKAPEFAEGKRVLVVGFNSSGSDIAVESIEAAERVLHSSFSRESWARRVFERLGMKVDWMHTRVTSMNDNVVFTKGGTEIEKGLMWATGIESKGFPKMHGLLQRHNVILDDVPNRLVHGKVVKPGDIEFCDESNVFEDGTVPQAVNAIAQTGYKFAFNFLPEAGKEVEKNVVYDKHGLMAPIGPKNTIAVLGFKLKSGFFAPFWDAQARWATRVFGSNKLSLSHMTWMMDIIKDKRSMILRVGKSKRHTLQTDFMTWMEDLCAEIGAKPDFWKFLWTDPKLALEVIFGPCTPYQFRLVGPGKWEGARNAIYTMDWRVTKPMRTRVPVGDQSRSSSFRSLKIAAGAVAAFVFFLFYSY

Ligand/Cofactor

FAD

CC1=CC2=C(C=C1C)N(C3=NC(=O)NC(=O)C3=N2)CC(C(C(COP(=O)(O)OP(=O)(O)OCC4C(C(C(O4)N5C=NC6=C(N=CN=C65)N)O)O)O)O)O

Validation Metrics

PLDDT72.0
NLMSIM85.0
AACOMP93.5
Seqdif (SeqID)56.4 (UZZ64696.1)
Structdif (F-Target)11.3 (6se3 E)

ProtNLM

NameScore
Dimethylaniline monooxygenase [N-oxide-forming]0.175
Dimethylaniline monooxygenase (N-oxide forming)0.136
1.-.-.-0.128
Flavin-containing monooxygenase0.127
1.14.13.80.117
Dimethylaniline monooxygenase0.046
Designed by MP, using an AMD MI250 GPU