M2PB8

Prompt

1.14.11.66

Oxidoreductases. Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporated need not be derived from O2. With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors. [histone H3]-trimethyl-L-lysine(9) demethylase.

AI Generated Sequence

248 AAs

MAGEDHSALNPGCKIMTFRPTMEEFRDFGKYVAYVESQGAHRAGLAKVIPPKEWDPRQCYDDIDDMLIDAPIQQMVTGQSGLFTQYNIQKKAMTVQEFRRIANSDMYCTPRYTDFEDLERKYWKNLTFVSPIYGADVSGSLYDEDVAEWNIGRLRTILDMVEEESGTTIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGEPKSWYAVPPEHGKRLERLAKGFFPGSSQGCDAFLRHKMTLISP

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT	82.0
NLMSIM	85.0
AACOMP	92.9
Seqdif (SeqID)	12.9 (XP_060001469.1)
Structdif (F-Target)	9.2 (2w2i A)

ProtNLM

Name	Score
Lysine-specific demethylase 4B	0.271
Lysine (K)-specific demethylase 4B	0.164
Lysine-specific demethylase 4D	0.115
Lysine-specific demethylase 4D-like	0.051
Lysine-specific demethylase 4B-like	0.040
Lysine (K)-specific demethylase 4A, genome duplicate b	0.039