M2OHH

Prompt

6.5.1.8

Ligases. Forming phosphoric ester bonds. Forming phosphoric ester bonds. 3'-phosphate/5'-hydroxy nucleic acid ligase.

AI Generated Sequence

519 AAs

MTDEQIRELRELREEIERHDYAYYVLDNPLISDAEYDRLRHELLALEAEHPELITPDSPTQRVGAAPLSKFPQVTHAVPMLSLDKAFDEDELRAWDRRVRKLLGVEGAVEYTCEPKFDGLAVSLRYENGVLVGAATRGDGTTGEDVTANVRTIRSVPLKLHGDNVPALLEVRGEVFMPKAAFLKLNEARLAAGEKTFANPRNAAAGSLRQLDPKITASRPLSFFAYGVGVVEGAELADTHSERLQQLKTWGLPVPDELKLVKGIEGVLAYYRDVEERRDSLPFEIDGVVFKVDSIALQERLGFVARAPRWATAFKFPAQEQLTVLEDVVVQVGRTGAVTPVARLKPVFVGGVTVSNATLHNADEVARLDVRIGDTVIIRRAGDVIPEVVGVVLEDRPEGTRPFVVPEHCPVCGSEVVRVEGEAVLRCTGGLACPAQRKEALKHFVSRDALDVEGLGDKLIDQLVDKGMVHSPADLFKLTKDQLTPLEGMGEKSAQNLVNALEASKQTTLPRFLYALGIR

Ligand/Cofactor

ATP

C1=NC(=C2C(=N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)N

Validation Metrics

PLDDT	86.9
NLMSIM	90.0
AACOMP	92.6
Seqdif (SeqID)	30.1 (WP_161584037.1)
Structdif (F-Target)	6.8 (3bac 2)

ProtNLM

Name	Score
DNA ligase	0.409
6.5.1.2	0.321
Polydeoxyribonucleotide synthase [NAD(+)]	0.265
NAD-dependent DNA ligase LigA	0.002
DNA ligase (NAD(+))	0.000
ATP-dependent DNA ligase	0.000