M2NT2

Prompt

2.1.1.67

Transferases. Transferring one-carbon groups. Methyltransferases. thiopurine S-methyltransferase.

AI Generated Sequence

267 AAs
MEPSFWQERWAANRIGFHQEDVNPLLLRHWFPGLPLPGARVFVPLCGKSLDMCWLAGQGHEVLGVELSELAVRDFFREEGLEPEVTELGPHRRYRSGEVELWCGDIFDLRAETIGDCDAVYDRAALIALPPEMRERYAAHLAALLPPGGRGLLVTLDYPQAEMAGPPFAVPAAEVRRLFGDGWEVRCLERPDVLAEHPRFLAKGVPRLEERVYRLRRAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Ligand/Cofactor

S-adenosylmethionine

C[S+](CCC(C(=O)[O-])N)CC1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)O)O

Validation Metrics

PLDDT94.7
NLMSIM75.0
AACOMP80.2
Seqdif (SeqID)36.1 (WP_096821079.1)
Structdif (F-Target)10.5 (2gb4 A)

ProtNLM

NameScore
Thiopurine S-methyltransferase0.466
2.1.1.670.374
Thiopurine methyltransferase0.143
Thiopurine s-methyltransferase0.000
Ubiquinone biosynthesis O-methyltransferase, mitochondrial0.000
S-adenosyl-L-methionine-dependent methyltransferase0.000
Designed by MP, using an AMD MI250 GPU