M2KWY

Prompt

2.7.11.31

Transferases. Transferring phosphorus-containing groups. Protein-serine/threonine kinases. [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase.

AI Generated Sequence

475 AAs
MTTDSRIPGFRKLTVAERLELLAERAGLTDEERAALAGAGGLPLDVADRMIENVIGTFGLPLGLATNFLVNGRDYLVPMAVEEPSVVAAVSYMAKLAREAGGFATASDGPLMIGQVQVLGVADPHAAREKILAAKAEILELANARDPTLVSLRGGCRDIEVHVFPTPRGPMVVVHLLVDTVDAMGANTVNSMAEAVAPLIETITGGQVRLRIFSNLADRALARARVTVPVEALAGGEIDGAEVVDRILAAYAFAAVDPYRAATHNKGIMNGIDAVAVATGNDWRAVEAGAHAYAARDGRYRSLTTWEKDADGALVGTLEMPMAVGLVGGATRTHPAARLALKLLGVQSARELAQVAASVGLAQNLAALRALATEGIQRGHMALHARNLALAAGAAGELIDLVAARLVAAGDVRLDRAREVLAAREAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Ligand/Cofactor

NADPH

C1C=CN(C=C1C(=O)N)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)OP(=O)(O)O)O)O)O

Validation Metrics

PLDDT92.8
NLMSIM60.0
AACOMP80.2
Seqdif (SeqID)29.7 (WP_034397778.1)
Structdif (F-Target)5.1 (4i4b A)

ProtNLM

NameScore
HMG-CoA reductase0.408
1.1.1.880.275
3-hydroxy-3-methylglutaryl coenzyme A reductase0.275
Hydroxymethylglutaryl-CoA reductase, degradative0.026
1.1.1.340.006
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase0.000
Designed by MP, using an AMD MI250 GPU