M2HS3

Prompt

1.6.99.2

Oxidoreductases. Acting on NADH or NADPH. With other acceptors. Transferred entry: 1.6.5.2.

AI Generated Sequence

158 AAs
MKKVVVVGGGFAGVELAGELHDFVKDTLKKYFPNIDENLKITLVEASERILPAFPEKISQYAVKQLEDRGVEVLTNSMVKSVKADGVVLKDGKEIPTDLVIAVGSQSNTFGTPGVKEHAFFLKEISDAIEIRNHILNCFEKAYLPTTDEERKRLLSFV

Ligand/Cofactor

NADH

C1C=CN(C=C1C(=O)N)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O

Validation Metrics

PLDDT83.8
NLMSIM85.0
AACOMP90.7
Seqdif (SeqID)50.5 (GFZ48217.1)
Structdif (F-Target)29.1 (4nwz 3)

ProtNLM

NameScore
Pyr_redox_2 domain-containing protein0.477
NADH dehydrogenase0.130
FAD-dependent oxidoreductase0.106
NAD(P)/FAD-dependent oxidoreductase0.074
Pyridine nucleotide-disulfide oxidoreductase0.059
1.6.99.30.022
Designed by MP, using an AMD MI250 GPU