M2EUG

Prompt

1.14.13.33

Oxidoreductases. Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporated need not be derived from O2. With NADH or NADPH as one donor, and incorporation of one atom of oxygen. 4-hydroxybenzoate 3-monooxygenase [NAD(P)H].

AI Generated Sequence

452 AAs

MRTQVAIIGAGPSGLLLGQLLHQAGIDTVILERQSGDYVLGRIRAGVLEQGTVDLLREAGVAERMHAEGLVHDGIELAFAGRRMRIDLHALTGGKHVTVYGQTELTRDLMAARAAAGATIIYGAEDVQPHDFDGDAPYVTYVKDGQTCRIDCDFIAGCDGFHGVSRKSIPAGVLKEYERVYPFGWLGILADTPPVSHELIYANHERGFALCSMRSLTRSRYYLQVPLDDKVEAWSDERFWDELKARLPEHLADKLVTGPSIEKSIAPLRSFVVEPMQYGRLFLAGDAAHIVPPTGAKGLNLAASDVNYLYRILKKVYLEGRSGLLDRYSQICLARVWKAERFSWWMTSMLHRFPDQDAFGQKIQAAELDYFLGSRAAQTTIAENYVGLPYEAIEGAREHIFRGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG

Ligand/Cofactor

NADH

C1C=CN(C=C1C(=O)N)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O

Validation Metrics

PLDDT	86.2
NLMSIM	95.0
AACOMP	87.1
Seqdif (SeqID)	20.1 (WP_280325438.1)
Structdif (F-Target)	1.0 (1dob 2)

ProtNLM

Name	Score
1.14.13.2	0.446
4-hydroxybenzoate 3-monooxygenase	0.407
P-hydroxybenzoate hydroxylase	0.085
4-hydroxybenzoate hydroxylase	0.031
P-hydroxybenzoate 3-monooxygenase	0.013
FAD_binding_3 domain-containing protein	0.001