M23YZ

Prompt

2.1.1.297

Transferases. Transferring one-carbon groups. Methyltransferases. peptide chain release factor N(5)-glutamine methyltransferase.

AI Generated Sequence

330 AAs

MTLEQALRWASELLSRGSESPARDARLLLCHVLGLSRLQLYTHWDRPLPEEEQQRFRELVQRRLEGEPLAHILGHREFWSRELLVNPRVLIPRPETEVLVEQALELVPRPGPPRLLDLGTGSGAIALSLAKERPDCQVTAVDISEEALAVARRNRERHGLRNRVTFLQGSWFSPLEGRFDLIVSNPPYISSEDMPSLPQDVRYEPRLALVAGEDGLDYIRRIAEQAPRFLRPGGWLLAEIGWKQGEAVRLLFAEQGFRQVSTHRDLDGRDRCVTGARWRPGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG

Ligand/Cofactor

S-adenosylmethionine

C[S+](CCC(C(=O)[O-])N)CC1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)O)O

Validation Metrics

PLDDT	89.8
NLMSIM	70.0
AACOMP	83.1
Seqdif (SeqID)	41.6 (WP_046657690.1)
Structdif (F-Target)	4.5 (1t43 A)

ProtNLM

Name	Score
RF MTase	0.222
Release factor glutamine methyltransferase	0.215
Protein-(glutamine-N5) MTase PrmC	0.162
N5-glutamine methyltransferase PrmC	0.136
Protein-glutamine N-methyltransferase PrmC	0.131
2.1.1.297	0.129