M23QC

Prompt

1.13.11.57

Oxidoreductases. Acting on single donors with incorporation of molecular oxygen (oxygenases). The oxygen incorporated need not be derived from O2. With incorporation of two atoms of oxygen. gallate dioxygenase.

AI Generated Sequence

279 AAs
MAGIIGGLGTSHSPIIGYALDKAKDYDPKYQPVFEGYQPLSKWLAEKKPDVLLIFYDNHVTSFFFDKYPTFKLGVDRQYEDEDEGGGRPLPPVKGHPELARHIAQSLMADEFDMTIFNDKLVDHGCTVPLSMLYPNTPNGWPWKVIPLQMNVVQFPTPSGRYCFKLGQAIRRAIEYPEDLKVHVVIATGGMSSHVHGERAGFNNMEWDNRFLDLLREDPEKLTKMTPYEYAELAGESGEIVMMWTVMRGALGSKVTELHRSYYMPLSNYMAVWILEEKA

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT81.8
NLMSIM90.0
AACOMP93.2
Seqdif (SeqID)39.1 (WP_099740153.1)
Structdif (F-Target)4.8 (1bou D)

ProtNLM

NameScore
Gallate dioxygenase0.234
LigB domain-containing protein0.191
Protocatechuate 4,5-dioxygenase beta chain0.156
Protocatechuate 3,4-dioxygenase0.144
1.13.11.80.060
Protocatechuate 4,5-dioxygenase beta subunit0.041
Designed by MP, using an AMD MI250 GPU