M217G

Prompt

1.1.1.375

Oxidoreductases. Acting on the CH-OH group of donors. With NAD(+) or NADP(+) as acceptor. L-2-hydroxycarboxylate dehydrogenase [NAD(P)(+)].

AI Generated Sequence

477 AAs

MKDFVIIGGGIIGMSTAMQLIDLYPDARIALLEKESGPACHQGTHNSGVIHSAVYYPQGSLKAQFCLAGNRATATFCDQNGIRYDNCGKMLVATSELEMERMRALWERTAANGIEREWLNAAELREREPNITGVGLIFVPSGGILSYREVTAAMAKAFQAARGGVIYNAEVSALGEKHAGVVIRTRQGGEYEASTLIASAGLMADRLVKMLGLEPGFIICPFRGEYFQLAPEHNKIVNHLIYPIPDPAMPFLGVHLTMRIGDSVTVGPNAVLAFKREGYRKRDVSFSDTLEILGSPGIRRVLQNHLASGLGEMKNSFCKSGYLRLQQVYCPSLTVSDLQPWPAGVRAQAVSPDGKLMDDFLVCGTPRTIHTANANSPAATSAIPIGAHVSGKVTALIREQSNPGRTLTRARSVDALHAAFANQAAVEAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT	92.5
NLMSIM	85.0
AACOMP	87.8
Seqdif (SeqID)	13.6 (MDW6926144.1)
Structdif (F-Target)	4.5 (8w7f C)

ProtNLM

Name	Score
L2HG dehydrogenase	0.302
L2HG:quinone oxidoreductase	0.259
1.1.5.13	0.232
L-2-hydroxyglutarate dehydrogenase	0.114
L-2-hydroxyglutarate dehydrogenase, mitochondrial	0.038
1.1.3.-	0.019