M1ZP2

Prompt

1.14.13.84

Oxidoreductases. Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporated need not be derived from O2. With NADH or NADPH as one donor, and incorporation of one atom of oxygen. 4-hydroxyacetophenone monooxygenase.

AI Generated Sequence

500 AAs
MAKKKIAVIGAGSGLGLALKALKKLGLPEVDYEVVDRTTNYWTWTPKLEGVATSTIESRIISQPLRMTFPDFPFHFRYGPYVNLHHLYEKYIKLADEYDFEILYDYLVMTVGSVSNTFGTPGVEQHNFTLKESQDAQHIRHRILNMCLAGYFPTPNIEERGRLTGFSIVGGGHTGVEFAAELHDFVKRVVGVGYPSIESDISVTLIEAAPRILSMFDKRLSAAVKETLKRGVDVQLRTTRVTEVTENTVLTKDGTEIPYKLMVWAAGVKAPGFPKLGDLDQRNGRLVTDNHLRVKGVDNVWAIGDCASVTVFKDGTFPPTAQVAQQTGLYVAKNFLKLLDGKEVKPFKYHDKGLMAILGNKNTVAPLGLNVFSGFIPFLWEAARVYLRVYLSRNKLSLLGMWALDFIFKRDRISRTIRRPSKTQIHLQFDWMDRVAAEIGGKKPFEYTFLLDDPKAKEYVWGGSTYDWQFELRPAKGDYEGRAIYALDTTGYVPRMKGVI

Ligand/Cofactor

NADH

C1C=CN(C=C1C(=O)N)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O

Validation Metrics

PLDDT76.8
NLMSIM70.0
AACOMP94.4
Seqdif (SeqID)63.3 (MBM4160284.1)
Structdif (F-Target)8.2 (4nwz A)

ProtNLM

NameScore
NAD(P)/FAD-dependent oxidoreductase0.446
FAD-dependent oxidoreductase0.123
Pyr_redox_2 domain-containing protein0.078
FAD-dependent pyridine nucleotide-disulfide oxidoreductase0.065
NADH dehydrogenase0.059
1.6.99.30.048
Designed by MP, using an AMD MI250 GPU