M1WJA

Prompt

1.2.1.85

Oxidoreductases. Acting on the aldehyde or oxo group of donors. With NAD(+) or NADP(+) as acceptor. 2-hydroxymuconate-6-semialdehyde dehydrogenase.

AI Generated Sequence

395 AAs

MKIAVAGAGAFGKKHLDGIANIDGVEVVSLIGRGLDKTAAFAAKYGIGHVYTDLAEALADPAVDAVILATPTQMHAPQTIACMKAGKHVQVEIPLADTLADADAVVAAQEKTGLVCMVGHTRRFNPSHQWVHKHIAAGELTIQQMDVQTYFFRRTNTNAWGKPRSWTDHLLWHHAAHTVDLFAYQTGAPIVKVHAIQGPIHPELGIAMDMSIQLKAASGAICTLSLSFNDDGPLGTFFRYIGDTGTYIARYDDLIVDGKTEEDIDVSVVDVSMNGIELQDREFFAAIREGREPNSSVAQVLPCYLVLDGVEKALHGGGAVKIAGFAPGAAIDTVAGVVAAGHGAGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT	83.1
NLMSIM	85.0
AACOMP	82.6
Seqdif (SeqID)	17.5 (HLG82647.1)
Structdif (F-Target)	12.4 (1evj C)

ProtNLM

Name	Score
Oxidoreductase	0.244
4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase	0.182
Gfo/Idh/MocA family oxidoreductase	0.154
4-carboxy-2-hydroxymuconate semialdehyde dehydrogenase	0.105
Oxidoreductase domain protein	0.040
Oxidoreductase domain-containing protein	0.027