M1WEA

Prompt

1.1.1.337

Oxidoreductases. Acting on the CH-OH group of donors. With NAD(+) or NADP(+) as acceptor. L-2-hydroxycarboxylate dehydrogenase (NAD(+)).

AI Generated Sequence

473 AAs
MYDFVIIGAGIIGMSTAMQLADVYPDARIALLEKESGPACHQTGHNSGVIHAGVYYTPGSLKAQFCLAGNRATKTFCDQNGIRYDVCGKMLVATSELEMERMRALWERTAANGIEREWLSAEELREREPNITGLGGIFVPSSGIVSYRETVAAMAKIFQARGGEIIYNAEVSALNEHKNGVVIRTRQGGEIEASTLIACSGLMADRLVKMLGLEPGFIICPFRGEYFRLAPEHQNIVNHLIYPIPDPAMPFLGVHLTRMIDGSVTVGPNAVLAFKREGYRKRDFSLSDTLEIFGSPGIRRVLQNHLRSGLGEMKNSLCKSGYLRLVQKYCPRLSLQDLQPWPAGVRAQAVSPDGKLIDDFLLVTTRESIHTCNAPSPALTSAIPLGAHIVSKVHTLRASHITPGRTLRAARSVDALHAAFDRAGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT90.0
NLMSIM70.0
AACOMP88.2
Seqdif (SeqID)6.6 (WP_000271974.1)
Structdif (F-Target)4.3 (8w7f C)

ProtNLM

NameScore
L2HG dehydrogenase0.349
L2HG:quinone oxidoreductase0.253
1.1.5.130.179
L-2-hydroxyglutarate dehydrogenase0.158
1.1.3.-0.028
L2HG oxidase0.003
Designed by MP, using an AMD MI250 GPU