M1IYO

Prompt

1.5.1.53

Oxidoreductases. Acting on the CH-NH group of donors. With NAD(+) or NADP(+) as acceptor. methylenetetrahydrofolate reductase (NADPH).

AI Generated Sequence

286 AAs
MKIKDFIKNKKFVFSAEFFPPKTEESIENIYKTIDELKELNPDFISVTYGAGGSTRERTLEIASKIQKDYGIETVAHLTCVDLTKEEITDILNKYKEEGIKNILALRGDLPKGEKFEATKDFKYADSQLIKFIKENGFDFCIGAACYPEGHPESPNFESDIEHLKKKVDAGTDFLITQMFFDNDKFYDFLDKIKAIGITVPIIPGIMPITNAKQLKRMTSLCGASIPSKFINILEKYKDNPEALKEAGIKYATEQIIDLIDNGVNGIHLYTMNKPEATKKIWESLK

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT90.1
NLMSIM85.0
AACOMP86.3
Seqdif (SeqID)40.7 (WP_106024320.1)
Structdif (F-Target)4.7 (7th5 B)

ProtNLM

NameScore
1.5.1.200.548
Methylenetetrahydrofolate reductase0.440
Methylenetetrahydrofolate reductase [NAD(P)H]0.004
Methylenetetrahydrofolate reductase (NAD(P)H)0.004
Methenyltetrahydrofolate cyclohydrolase0.001
5,10-methylenetetrahydrofolate reductase0.001
Designed by MP, using an AMD MI250 GPU
EC Repo - M1IYO | 310.ai