M12C9

Prompt

1.14.12.4

Oxidoreductases. Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporated need not be derived from O2. With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor. Transferred entry: 1.14.13.242.

AI Generated Sequence

282 AAs
MKKIVVVGGGFAGVELAGELAKKLGKKDYDITLVDRNNYHTFQPLLHQVATGTIESRSIDEPFRGHLKQRHNFHFQLGEVTDIDREAKKIQLAGVEDYVSYDYLVIGMGSVTNNFGIPGVKEHAIGLKSVEDALKIRHHVLNNFEKAYRLTTDEERKKLLTFAIVGGGATGVELAGELADIVKDLIPDYLPNIDLENMNITLIEAGDRILAAMPEKISAYAHKHLKEMGVEVLTNAMVTSYEGDGVKTKDGKFIETDMTVWATGVKASPVVKALGIETDNRG

Ligand/Cofactor

NADH

C1C=CN(C=C1C(=O)N)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O

Validation Metrics

PLDDT94.7
NLMSIM70.0
AACOMP91.9
Seqdif (SeqID)51.0 (WP_320705738.1)
Structdif (F-Target)7.6 (5kmq C)

ProtNLM

NameScore
FAD-dependent oxidoreductase0.330
NAD(P)/FAD-dependent oxidoreductase0.251
NADH dehydrogenase0.205
Pyridine nucleotide-disulfide oxidoreductase0.049
1.6.99.30.036
Pyr_redox_2 domain-containing protein0.035
Designed by MP, using an AMD MI250 GPU