M04NG

Prompt

1.14.13.n9

Oxidoreductases. Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporated need not be derived from O2. With NADH or NADPH as one donor, and incorporation of one atom of oxygen. Transferred entry: 1.14.13.149.

AI Generated Sequence

158 AAs
MKKVVVVGGGFAGVELAGELHDFVKDTLKKYFPNIDENLKITLVEASERILPAFPEKISQYAVKQLEDRGVEVLTNSMVKSVKADGVVLKDGKEIPTDLVIAVGSQSNTFGTPGVKEHAFFLKEISDAIEIRNHILNCFEKAYLPTTDEERKRLLSFV

Ligand/Cofactor

NADH

C1C=CN(C=C1C(=O)N)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O

Validation Metrics

PLDDT83.8
NLMSIM85.0
AACOMP90.7
Seqdif (SeqID)50.5 (GFZ48217.1)
Structdif (F-Target)29.1 (4nwz 3)

ProtNLM

NameScore
Pyr_redox_2 domain-containing protein0.477
NADH dehydrogenase0.130
FAD-dependent oxidoreductase0.106
NAD(P)/FAD-dependent oxidoreductase0.074
Pyridine nucleotide-disulfide oxidoreductase0.059
1.6.99.30.022
Designed by MP, using an AMD MI250 GPU