M026V

Prompt

2.3.1.161

Transferases. Acyltransferases. Transferring groups other than amino-acyl groups. lovastatin nonaketide synthase.

AI Generated Sequence

500 AAs
MAVVGGVNLLLGPGLTVGLARAGALSPDGRCKSFDAAADGYGRGEGCGVVLLKRLSDARRDGDRVLAVIRGSAVNQDGASTGLTAPNGPAQQRVIRAACAAAGLDPAAVGYVEAHGTGTTLGDPIEAQALAAVYGRGRPADAPLLLGSVKSNIGHTEAAAGVAGVIKVVLALRHGVLPPTLHFDRPSPHVDWAAAGVRLVTEALPWPATGRPRRAGVSSFGASGTNAHVILEQAPAPAPAAAAAAAPALPLVLSARTAAALRAQAARLAAHLAAHPGAALADVAHTLATGRAALAHRAAVVAADRAALAAGLAALAAGEPAPGVVTGVAAAGGRTAFLFTGQGSQWAGMGRELYAAFPVFAAALDAVCAALAPHLGRSLVDVLRGDAALLDRTAVAQPALFAVEVALAALWESWGVRPDAVVGHSVGEIAAAHVAGALSLEDAARLVTARGRLMQALPGGGAMAAVALPEAAVAARLAGLGGGGGGGGGGGGGGGGGGGG

Ligand/Cofactor

NADPH

C1C=CN(C=C1C(=O)N)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)OP(=O)(O)O)O)O)O

Validation Metrics

PLDDT93.3
NLMSIM70.0
AACOMP80.5
Seqdif (SeqID)37.0 (KIF04358.1)
Structdif (F-Target)13.9 (7s6b A)

ProtNLM

NameScore
SDR family NAD(P)-dependent oxidoreductase0.139
Carrier domain-containing protein0.119
Polyketide synthase0.086
Type I polyketide synthase0.082
Acyl transferase domain-containing protein0.069
Acyltransferase domain-containing protein0.052
Designed by MP, using an AMD MI250 GPU