MTY9E

Prompt

1.14.11.67

Oxidoreductases. Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporated need not be derived from O2. With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors. [histone H3]-trimethyl-L-lysine(4) demethylase.

AI Generated Sequence

927 AAs

MEPYGDDFIPPPEAPVFEPSWAEFRDPLGYIAKIRPIAEKSGICKIRPPADWQPPFAVEVDNFRFTPRIQRLNELEAQTRVKLNYLDQIAKFWEIQGSSKKIPNVERRILDLSFLSKIVVEEGGYEAICKDRRWARVAQRLNYPPGKNIGSLLRSHYERIVRYPEMYQSGANLVQCNTRHFDNEEKDKEYKPHSIPLRQSVQPSKFNSYGRRAKRLQPDPEPTEEDIEKHPELKKLQIYGAGPKMMGLGLMAKDKTLRKKDKEGSPEPTTKMTMRLRRNHSNAQFIDSYVCRMCGRGDEADRLLLCDGCDDNYHIFCLLPPLSRIPKGVWRCPKCVAEECKRPPEAFGFEQAREYTLRSFGEMADAFKADYFNMPVHMVPTELVEKEFWRLVNSIEEDVTVEYGADIASSKFGSGFPVSDSKRLLTPEEEEYATSGWNLNVMPVLEQSVLCHINADISGMTVPWLYVGMVFSAFCWHWEDHWSYSISYLHWGEPKTWYGVPSAAAEHLEEVMKKLTPELFDSQPDLLHQLVTLMNPNTLMSHGVPVVRTNQCAGEFVITFPRAYHSGFNQGYNFAEAVNFCTADWLPAGRQCIEHYRRLRRYCVFSHEELICKMAACPEKLDLNLAAAVHKDMFILVQEERRLRKGLLEKGIVEAEREAFELLPDDERQCIKCKTTCFLSALACYDCPDGLACLSHINDLCSCSSSRQRLRYRYTLDELPAMAHKLGVRAESFDTWASKVRVALEVEDGRKRSLEELRALESEARERRFPNSELLQRLKNCLESAEACVAKALGLLSGQEGDLYRMRAGELQLTVAELRAFLEQMNNLPCAMHQIGDVKGVLEQVEAYQAEAREALASLPSSPGLLQSLLERGQQLGVELPEAQQLQRAVEAARWLDEVKRLTAPSARGTLAVMRGLLVAGASLAPS

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT	81.1
NLMSIM	96.2
AACOMP	94.1
Seqdif (SeqID)	10.7 (XP_039076929.1)
Structdif (F-Target)	2.2 (6ein A)

ProtNLM

Name	Score
1.14.11.67	0.511
[Histone H3]-trimethyl-L-lysine(4) demethylase	0.451
Lysine demethylase 5C	0.006
Lysine-specific demethylase 5C	0.004
Jumonji/ARID domain-containing protein 1C	0.002
KDM5C	0.002