MF8Y3

Prompt

1.5.1.53

Oxidoreductases. Acting on the CH-NH group of donors. With NAD(+) or NADP(+) as acceptor. methylenetetrahydrofolate reductase (NADPH).

AI Generated Sequence

290 AAs
MTAPVLSFEFFPPKDAAGFERLWDAVRELAPLRPDFVSVTYGAGGSTRERTLDVVAEIHRETGLTPVAHLTCVGDSRAELEAILAGYAAAGVRRIVALRGDPPKGMAPFVPHPDFVAASAELVAGIRAIGDFHIGVAAYPEGHPEAPDPAADIANLKRKVDAGASFAITQFFFDADAYFRFRDACAAAGIDVPIVPGIMPITSFAQARRFAEMCGAHIPAWMAARFEAYGDDPASRRLVGADIATELCDRLIAEGVDRFHFYTLNRPDLTREICDRLGLRPAAAAAAAAA

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT91.7
NLMSIM85.0
AACOMP86.5
Seqdif (SeqID)39.8 (WP_189995140.1)
Structdif (F-Target)3.4 (1b5t B)

ProtNLM

NameScore
1.5.1.200.523
Methylenetetrahydrofolate reductase0.472
5,10-methylenetetrahydrofolate reductase0.001
Methylenetetrahydrofolate reductase (NAD(P)H)0.001
Methylenetetrahydrofolate reductase [NAD(P)H]0.001
Methenyltetrahydrofolate cyclohydrolase0.000
Designed by MP, using an AMD MI250 GPU
EC Repo - MF8Y3 | 310.ai