MQ3E6

Prompt

1.1.1.375

Oxidoreductases. Acting on the CH-OH group of donors. With NAD(+) or NADP(+) as acceptor. L-2-hydroxycarboxylate dehydrogenase [NAD(P)(+)].

AI Generated Sequence

506 AAs
MKDFVIIGAGIIGMSTAMQLIDKYPDARIDLLEKESGPACHQTGHNTGVIHSAVYYTPGSLKAQFCLAGNRATATFCDQNNIRYDVCGKMLVATSELEMERMRALWERTAANGIEREWLSAEELREREPNIAGLGGIFVPSSGIVSYREVTEAMAKIFQSKGGEIIYNAEVSALNEHKNGVVVRTRQGGEYEASTLIACSGLMARDLVKMLGLEPGFIICPFRGEYFQLAPEYHNIVLLHYIIPIDPAMPFLGVHLTRMIDGSVTVGPNAVLALKREGYRKKDFSFTDTYEIFGSNGIRQVLQHNLRSGLGEMKNSLVKSGYLRLVQKYCSRSLLNDLQPWPAGVRAQAVSPDGKLIDDFLFVTTPRSIHTCNAPSPAATSAIPIGAHIVSKVQTLRESQINPGRTLRAARSVDDLHAAFANSTAEVNTADHILRAGGSRLAARSVDDLHAAFNATSEVRYDSEGNIIYNASEVSARAREKIVLTALPQGRRLFEASVPVNQPLHR

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT81.5
NLMSIM85.0
AACOMP96.6
Seqdif (SeqID)11.4 (WP_000271974.1)
Structdif (F-Target)4.9 (8w7f C)

ProtNLM

NameScore
L2HG dehydrogenase0.314
L2HG:quinone oxidoreductase0.224
L-2-hydroxyglutarate dehydrogenase0.165
1.1.5.130.165
1.1.3.-0.076
L-2-hydroxyglutarate oxidase0.006
Designed by MP, using an AMD MI250 GPU