M313G

Prompt

1.1.5.13

Oxidoreductases. Acting on the CH-OH group of donors. With a quinone or similar compound as acceptor. (S)-2-hydroxyglutarate dehydrogenase.

AI Generated Sequence

479 AAs

MYDFVIIGAGIIGMSTAMQLIDVYPDARIALLEKESGPACHQTGHENSVIHAGVYYTPGSLKAQFCLAGNRATKTFCDQNGIRYDNCGKMLVATSELEMERMRALWEATAANGIEREWLSAERLRERTPNITGLGGIFVPSSGIVSRDAVAAAMAKIFQSRGGEIIYNAEVSALGEHKNGVVIRTRQGGEIEASTLIACSGLMAADRLVKLGIEPGFIICPFRGEYFRLAPEHNQIVVHLIYPIPPAATPFLGVHLTRMIDGSVTVGPNAVLAFKREGYRKRDFSLSDTLEILPSPGIRRVLQNHLRSGLGEKMNRSLKSGYLRLVQKYCPSRSLQDLQPWPAGVRAQAVSPDGKLIDDFLVVTTRSIIHTANAPSLPATSAIPLIGAHISKVQTLLASQSINPGRTLAARSVDALHAAFNRQGEIIAAGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG

Ligand/Cofactor

L-2-hydroxyglutarate

C(CC(=O)O)C(C(=O)O)O

Validation Metrics

PLDDT	80.2
NLMSIM	90.0
AACOMP	88.3
Seqdif (SeqID)	10.8 (HAN4259001.1)
Structdif (F-Target)	5.2 (8w7f C)

ProtNLM

Name	Score
L2HG dehydrogenase	0.313
L2HG:quinone oxidoreductase	0.256
1.1.5.13	0.214
L-2-hydroxyglutarate dehydrogenase	0.167
1.1.3.-	0.020
L2HG oxidase	0.003